ANTIMICROBIAL PEPTIDE LL-37 FACILITATES INTRACELLULAR UPTAKE OF RNA APTAMER APT 21-2 WITHOUT INDUCING AN INFLAMMATORY OR INTERFERON RESPONSE

Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response

RNA aptamers are synthetic single stranded RNA oligonucleotides that function analogously to antibodies.Recently, they have shown promise for use in treating inflammatory skin disease as, unlike antibody-based biologics, they are able to enter the skin following topical administration.However, it is important to understand the inflammatory milieu i

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Arthroscopic Decompression of a Popliteal Cyst

Background: Popliteal (Baker) cysts are enlarged gastrocnemius-semimembranosus bursae leading to swelling in the popliteal fossa.Surgical decompression and capsulectomy is the definitive treatment for symptomatic cysts with arthroscopic or open decompression.Arthroscopic decompression is minimally invasive, entails lower risks, and allows for earli

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Psychological Impact of NBS for CF

Newborn screening for cystic fibrosis has resulted in diagnosis often before symptoms are recognised, leading to benefits including reduced disease severity, decreased burden of care, and lower costs.The psychological impact of this often unsought diagnosis on the parents of seemingly well earthbath facial wipes children is less well understood.The

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